[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …
due to their ability to augment experimental and clinical investigations. Cardiac …
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Translational models and tools to reduce clinical trials and improve regulatory decision making for QTc and proarrhythmia risk (ICH E14/S7B updates)
DG Strauss, WW Wu, Z Li, J Koerner… - Clinical Pharmacology …, 2021 - Wiley Online Library
After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …
Mechanistic model‐informed proarrhythmic risk assessment of drugs: review of the “CiPA” initiative and design of a prospective clinical validation study
The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is developing and
validating a mechanistic‐based assessment of the proarrhythmic risk of drugs. CiPA …
validating a mechanistic‐based assessment of the proarrhythmic risk of drugs. CiPA …
Today's challenges to de-risk and predict drug safety in human “mind-the-gap”
RJ Weaver, JP Valentin - Toxicological Sciences, 2019 - academic.oup.com
Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …
multiple target organs,(2) to predict and risk assess with certainty against drug safety …
Comprehensive in vitro proarrhythmia assay (CiPA) update from a cardiac safety research consortium/health and environmental sciences institute/FDA meeting
DG Strauss, G Gintant, Z Li, W Wu… - Therapeutic …, 2019 - journals.sagepub.com
A Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/FDA-
sponsored Think Tank Meeting was convened in Washington, DC, on May 21, 2018, to bring …
sponsored Think Tank Meeting was convened in Washington, DC, on May 21, 2018, to bring …
A computational pipeline to predict cardiotoxicity: from the atom to the rhythm
PC Yang, KR DeMarco, P Aghasafari, MT Jeng… - Circulation …, 2020 - Am Heart Assoc
Rationale: Drug-induced proarrhythmia is so tightly associated with prolongation of the QT
interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval …
interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval …