Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

The characterization of mouse models of human disease is essential for understanding the
underlying pathophysiology and developing new therapeutics. Many diseases are often …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion
that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide …

Huntington's disease (HD) is one of the few neurodegenerative diseases with a known
genetic cause, knowledge that has enabled the creation of animal models using genetic …

Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N
terminus of huntingtin. This mutation reduces levels of BDNF in the striatum, likely by …

Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease
caused by an increase in the number of polyglutamine residues in the huntingtin (Htt) …

Huntington's disease is a neurodegenerative disorder, caused by an elongation of CAG
repeats in the huntingtin gene. Mice with an insertion of an expanded polyglutamine repeat …

Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene
(HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We …

Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by
expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures …