Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis

L Edgar, N Akbar, AT Braithwaite, T Krausgruber… - Circulation, 2021 - Am Heart Assoc
Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

J Doffo, SA Bamopoulos, H Köse… - Proceedings of the …, 2022 - National Acad Sciences
Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance.
The proapoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma …

Non-apical mitoses contribute to cell delamination during mouse gastrulation

E Despin-Guitard, VS Rosa, S Plunder… - Nature …, 2024 - nature.com
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells
divide more frequently at the primitive streak, and half of those divisions happen away from …

Aberrations of chromosomes 1 and 16 in breast cancer: a framework for cooperation of transcriptionally dysregulated genes

AP Privitera, V Barresi, DF Condorelli - Cancers, 2021 - mdpi.com
Simple Summary Classical cytogenetic studies in breast cancer have identified frequent
chromosomal aberrations that produce an increased gene copy number in chromosome 1q …

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

M Toriseva, I Björkgren, A Junnila, A Mehmood… - Cellular and Molecular …, 2024 - Springer
Apart from the androgen receptor, transcription factors (TFs) that are required for the
development and formation of the different segments of the epididymis have remained …

Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells

TL Messier, JR Boyd, JAR Gordon, CE Tye, NA Page… - Plos one, 2022 - journals.plos.org
Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene
(BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) …

Occurrence of non-apical mitoses at the primitive streak, induced by relaxation of actomyosin and acceleration of the cell cycle, contributes to cell delamination during …

E Despin-Guitard, S Plunder, N Mathiah… - bioRxiv, 2024 - biorxiv.org
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells at the
primitive streak divide more frequently that in the rest of the epiblast, and half of those …

Drug repositioning for immunotherapy in breast cancer using single-cell analysis

E Mohammadi, S Dashti, N Shafizade, H Jin… - npj Systems Biology …, 2024 - nature.com
Immunomodulatory peptides, while exhibiting potential antimicrobial, antifungal, and/or
antiviral properties, can play a role in stimulating or suppressing the immune system …

UID-Dual Transcriptome Sequencing Analysis of the Molecular Interactions between Streptococcus agalactiae ATCC 27956 and Mammary Epithelial Cells

J Gong, T Li, Y Li, X Xiong, J Xu… - Animals: an Open …, 2024 - pmc.ncbi.nlm.nih.gov
Simple Summary The prevention and control of subclinical mastitis in dairy cows remains
challenging. The pathogen Streptococcus agalactiae ATCC 27956 is a major Gram-positive …

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation

C Trepicchio, G Rauner, N Traugh, M Parrish… - bioRxiv, 2024 - biorxiv.org
The human breast is complex and comprised of multi-lineage and multi-structural elements.
Recent work has shown that epithelial stem and progenitor cells use the collagen receptor …