Molecular pathology of endometrial carcinoma

X Matias‐Guiu, J Prat - Histopathology, 2013 - Wiley Online Library
This review paper discusses the main molecular alterations of endometrial carcinoma, the
most common cancer of the female genital tract. Two clinicopathological variants are …

Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics

A Sorolla, E Wang, E Golden, C Duffy, ST Henriques… - Oncogene, 2020 - nature.com
In molecular cancer therapeutics only 10% of known cancer gene products are targetable
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …

The role of the inflammatory microenvironment in thyroid carcinogenesis

LL Cunha, MA Marcello, LS Ward - Endocrine-related cancer, 2014 - erc.bioscientifica.com
Immune responses against thyroid carcinomas have long been demonstrated and
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …

Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer

L Alonso-Alconada, L Muinelo-Romay, K Madissoo… - Molecular cancer, 2014 - Springer
Background About 20% of patients diagnosed with endometrial cancer (EC) are considered
high-risk with unfavorable prognosis. In the framework of the European Network for …

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

O Draghiciu, HW Nijman, BN Hoogeboom… - …, 2015 - Taylor & Francis
The high efficacy of therapeutic cancer vaccines in preclinical studies has yet to be fully
achieved in clinical trials. Tumor immune suppression is a critical factor that hampers the …

From seabed to bedside: A review on promising marine anticancer compounds

E Wang, MA Sorolla, PD Gopal Krishnan, A Sorolla - Biomolecules, 2020 - mdpi.com
The marine environment represents an outstanding source of antitumoral compounds and,
at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide …

Peptides, proteins and nanotechnology: A promising synergy for breast cancer targeting and treatment

A Sorolla, MA Sorolla, E Wang… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction The use of nanoparticles for breast cancer targeting and treatment has become
a reality. They are safe and possess interesting peculiarities such as the unspecific …

Design and characterization of ascorbic acid based therapeutic deep eutectic solvent as a new ion-gel for delivery of sunitinib malate

M Mokhtarpour, H Shekaari, A Shayanfar - Journal of Drug Delivery …, 2020 - Elsevier
Ion-gel systems possess many favorable features to apply for the encapsulation, protection,
and release of bioactive agents in the pharmaceutical science. The ion-gels can reinforce …

Autophagy inhibition enhances sunitinib efficacy in clear cell ovarian carcinoma

L DeVorkin, M Hattersley, P Kim, J Ries… - Molecular Cancer …, 2017 - AACR
Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that
exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies …

Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by …

KQ Tran, AS Tin, GL Firestone - Anti-cancer drugs, 2014 - journals.lww.com
Relatively little is known about the antiproliferative effects of artemisinin, a naturally
occurring antimalarial compound from Artemisia annua, or sweet wormwood, in human …