Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the
side chain of acetylated lysine residues in cytoplasmic proteins such as α-tubulin and …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-
binding group (ZBG), which displays superior pharmacokinetic properties to the current …

Idiopathic pulmonary fibrosis is incurable, and its progression is difficult to control and thus
can lead to pulmonary deterioration. Pan-histone deacetylase inhibitors such as SAHA have …

Histone deacetylase 6 (HDAC6) plays a key role in a variety of neurological disorders, which
makes it attractive drug target for the treatment of Alzheimer's disease, Parkinson's disease …

This work presents the design and synthesis of a series of new quinazolin-4-one derivatives,
based on the established effectiveness of quinazoline-based small molecules as anticancer …

Glioblastoma is the most fatal type of primary brain cancer, and current treatments for
glioblastoma are insufficient. HDAC6 is overexpressed in glioblastoma, and siRNA …

A series of novel quinazoline-4-(3H)-one derivatives were designed and synthesized as
histone deacetylase 6 (HDAC6) inhibitors based on novel quinazoline-4-(3H)-one as the …