Nucleases: diversity of structure, function and mechanism
W Yang - Quarterly reviews of biophysics, 2011 - cambridge.org
Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes
E Wahle, GS Winkler - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Shortening and removal of the 3′ poly (A) tail of mature mRNA by poly (A)-specific 3′
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …
The Ccr4–not complex
MA Collart, OO Panasenko - Gene, 2012 - Elsevier
The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …
at the level of many different cellular functions to regulate gene expression. Two enzymatic …
Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems
A Siwaszek, M Ukleja, A Dziembowski - RNA biology, 2014 - Taylor & Francis
The process of mRNA decay and surveillance is considered to be one of the main
posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of …
posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of …
PDE12 removes mitochondrial RNA poly (A) tails and controls translation in human mitochondria
Polyadenylation of mRNA in human mitochondria is crucial for gene expression and
perturbation of poly (A) tail length has been linked to a human neurodegenerative disease …
perturbation of poly (A) tail length has been linked to a human neurodegenerative disease …
The intrinsic structure of poly (A) RNA determines the specificity of Pan2 and Caf1 deadenylases
Abstract The 3′ poly (A) tail of messenger RNA is fundamental to regulating eukaryotic
gene expression. Shortening of the poly (A) tail, termed deadenylation, reduces transcript …
gene expression. Shortening of the poly (A) tail, termed deadenylation, reduces transcript …
Reconstitution of targeted deadenylation by the Ccr4-Not complex and the YTH domain protein Mmi1
JAW Stowell, MW Webster, A Kögel, J Wolf, KL Shelley… - Cell reports, 2016 - cell.com
Ccr4-Not is a conserved protein complex that shortens the 3′ poly (A) tails of eukaryotic
mRNAs to regulate transcript stability and translation into proteins. RNA-binding proteins are …
mRNAs to regulate transcript stability and translation into proteins. RNA-binding proteins are …
The Ccr4-Not complex: architecture and structural insights
MA Collart, OO Panasenko - Macromolecular Protein Complexes: Structure …, 2017 - Springer
Abstract The Ccr4-Not complex is an essential multi-subunit protein complex that plays a
fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that …
fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that …
Poly (A)-specific ribonuclease (PARN): an allosterically regulated, processive and mRNA cap-interacting deadenylase
A Virtanen, N Henriksson, P Nilsson… - Critical reviews in …, 2013 - Taylor & Francis
Deadenylation of eukaryotic mRNA is a mechanism critical for mRNA function by influencing
mRNA turnover and efficiency of protein synthesis. Here, we review poly (A)-specific …
mRNA turnover and efficiency of protein synthesis. Here, we review poly (A)-specific …
Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex
The CCR4 and CAF1 deadenylases physically interact to form the CCR4-CAF1 complex
and function as the catalytic core of the larger CCR4-NOT complex. Together, they are …
and function as the catalytic core of the larger CCR4-NOT complex. Together, they are …