miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways
Micro RNAs (miRNA) negatively regulate protein-coding genes at the posttranscriptional
level and are critical in tumorigenesis. Schwannomas develop from proliferation of …
level and are critical in tumorigenesis. Schwannomas develop from proliferation of …
[HTML][HTML] Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth
S Dilwali, MC Briët, SY Kao, T Fujita, LD Landegger… - Molecular …, 2015 - Elsevier
Vestibular schwannomas (VSs), the most common tumors of the cerebellopontine angle,
arise from Schwann cells lining the vestibular nerve. Pharmacotherapies against VS are …
arise from Schwann cells lining the vestibular nerve. Pharmacotherapies against VS are …
[图书][B] OMICS: biomedical perspectives and applications
D Barh, K Blum, MA Madigan - 2016 - books.google.com
A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …
applications of omics in bioinformatics, cancer research and therapy, diabetes research …
Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas
Tumor‐specific alterations at the p53 gene locus in 30 human vestibular schwannomas (VS)
comprising 10 confirmed NF2 cases and 20 sporadic cases were analyzed. We found loss of …
comprising 10 confirmed NF2 cases and 20 sporadic cases were analyzed. We found loss of …
Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors
J Mathivanan, K Rohini, ML Gope, B Anandh… - Molecular and cellular …, 2007 - Springer
A total of 40 human brain tumor samples were analyzed for tumor-specific alterations at the
RB1 gene locus. Gliomas were more prevalent in younger males and meningiomas in older …
RB1 gene locus. Gliomas were more prevalent in younger males and meningiomas in older …
Sodium butyrate modulates pRb phosphorylation and induces cell death in human vestibular schwannomas in vitro
In the present study, effect of Na-Bu on the pRb phosphorylation was analysed in the
primary cultures of 12 VS tumors. Primary cultures of VS tumors were established from the …
primary cultures of 12 VS tumors. Primary cultures of VS tumors were established from the …
Functional modulation of the p53 gene and its protein in human brain tumors
The primary human brain tumors account for less than 2% of all human cancers but yet
cause a disproportionate burden of cancer related morbidity and mortality. These are the …
cause a disproportionate burden of cancer related morbidity and mortality. These are the …
[HTML][HTML] BAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro
Background: Disrupted kinase and signaling pathways are found in many human cancers
and they are implicated in carcinogenesis. Therefore, kinases have been important targets …
and they are implicated in carcinogenesis. Therefore, kinases have been important targets …
The tumor suppressor gene retinoblastoma (RB1) in human vestibular schwannomas
AHPP Dayalan, R Thomas, M Jothi… - Annals of …, 2010 - annalsofneurosciences.org
Tumorigenesis is a multistep process where normal control of cell proliferation and cell-cell
interactions are lost and this leads to transformation of normal cells into tumor cell …
interactions are lost and this leads to transformation of normal cells into tumor cell …
Possible role of the tumor suppressor gene retinoblastoma (RB1) in human brain tumor development
Human brain tumors are a group of tumors that primarily originate from the central nervous
system. These tumors vary in their etiology, histology, biology, prognosis and treatment. The …
system. These tumors vary in their etiology, histology, biology, prognosis and treatment. The …