Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …

Ubiquitination plays an important role in many cellular processes and is implicated in many
diseases. Experimental identification of ubiquitination sites is challenging due to rapid …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Carbon Catabolite Repression (CCR) has fascinated scientists and researchers around the
globe for the past few decades. This important mechanism allows preferential utilization of …

Protein ubiquitylation is a widespread post-translational modification, regulating cellular
signalling with many outcomes, such as protein degradation, endocytosis, cell cycle …

Clathrin-mediated endocytosis in the budding yeast Saccharomyces cerevisiae involves the
ordered recruitment, activity and disassembly of nearly 60 proteins at distinct sites on the …

The heat-shock response is a complex cellular program that induces major changes in
protein translation, folding and degradation to alleviate toxicity caused by protein misfolding …

Many plasma membrane transporters in yeast are endocytosed in response to excess
substrate or certain stresses and degraded in the vacuole. Endocytosis invariably requires …

Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality
control,,–. They contain around 1,000 different proteins that often assemble into complexes …