Naive CD4+ T cells give rise to T-helper-cell subsets with functions that are tailored to their
respective roles in host defence. The specification of T-helper-cell subsets is controlled by …

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and …

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …

After antigen encounter by CD4+ T cells, polarizing cytokines induce the expression of
master regulators that control differentiation. Inactivation of the histone methyltransferase …

The roles of EZH2 in various subsets of CD4+ T cells are controversial and its mechanisms
of action are incompletely understood. FOXP3-positive Treg cells are a critical helper T cell …

There is increasing evidence supporting the role of members of the polycomb group (PcG)
gene family in tumor development and progression. However, their precise role in …

An estimated 300 million people currently suffer from asthma, which causes approximately
250 000 deaths a year. Allergen‐specific T‐helper (Th) cells produce cytokines that induce …

Seminal discoveries have established that epigenetic modifications are important for driving
tumor progression. Polycomb group (PcG) proteins are highly conserved epigenetic …

Inflammatory bowel disease (IBD) represents a prominent chronic immune-mediated
inflammatory disorder, yet its etiology remains poorly comprehended, encompassing …

Differentiation of naïve CD4+ T cells into effector (Th1, Th2, and Th17) and induced
regulatory (iTreg) T cells requires lineage-specifying transcription factors and epigenetic …