Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

M Matsuo, K Kurihara - Nature communications, 2021 - nature.com
The hypothesis that prebiotic molecules were transformed into polymers that evolved into
proliferating molecular assemblages and eventually a primitive cell was first proposed about …

[HTML][HTML] Hydrophilic polymers: Current trends and visions for the future

N Bayliss, BVKJ Schmidt - Progress in Polymer Science, 2023 - Elsevier
Hydrophilic polymers are a major class of polymers in polymer science. They are found in
broad range of applications from superabsorbers to drug-delivery. In recent years, a plethora …

Automation and data-driven design of polymer therapeutics

R Upadhya, S Kosuri, M Tamasi, TA Meyer… - Advanced drug delivery …, 2021 - Elsevier
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …

Effect of solvent quality on the phase behavior of polyelectrolyte complexes

L Li, AM Rumyantsev, S Srivastava, S Meng… - …, 2020 - ACS Publications
The role of polyelectrolyte–solvent interactions, among other non-Coulomb interactions, in
dictating the thermodynamics and kinetics of polyelectrolyte complexation is prominent yet …

Advances in the structural design of polyelectrolyte complex micelles

AE Marras, JM Ting, KC Stevens… - The Journal of Physical …, 2021 - ACS Publications
Polyelectrolyte complex micelles (PCMs) are a unique class of self-assembled nanoparticles
that form with a core of associated polycations and polyanions, microphase-separated from …

Effect of charged block length mismatch on double diblock polyelectrolyte complex micelle cores

KC Stevens, AE Marras, TR Campagna, JM Ting… - …, 2023 - ACS Publications
Polyelectrolyte complex micelles are hydrophilic nanoparticles that self-assemble in
aqueous environments due to associative microphase separation between oppositely …

On complex coacervate core micelles: Structure-function perspectives

JR Magana, CCM Sproncken, IK Voets - Polymers, 2020 - mdpi.com
The co-assembly of ionic-neutral block copolymers with oppositely charged species
produces nanometric colloidal complexes, known, among other names, as complex …

Solid-to-liquid phase transition in polyelectrolyte complexes

S Meng, JM Ting, H Wu, MV Tirrell - Macromolecules, 2020 - ACS Publications
Strongly interacting polyelectrolyte complexes (PECs) are known to form solid precipitates
that can transform into liquid droplets upon the addition of salt to break intrinsic ionic …