Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

The regenerative potential of mammalian peripheral nervous system neurons after injury is
critically limited by their slow axonal regenerative rate. Regenerative ability is influenced by …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Neuronal microenvironment imbalance is associated with successive and irreversible
pathophysiological changes and insufficient functional restoration after peripheral nerve …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …

Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …