Biomechanical properties of cancer cells

G Runel, N Lopez-Ramirez, J Chlasta, I Masse - Cells, 2021 - mdpi.com
Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

Nanomechanics in monitoring the effectiveness of drugs targeting the cancer cell cytoskeleton

A Kubiak, T Zieliński, J Pabijan, M Lekka - International Journal of …, 2020 - mdpi.com
Increasing attention is devoted to the use of nanomechanics as a marker of various
pathologies. Atomic force microscopy (AFM) is one of the techniques that could be applied to …

Long term culturing of CHO cells: phenotypic drift and quality attributes of the expressed monoclonal antibody

R Kaur, R Jain, N Budholiya, AS Rathore - Biotechnology Letters, 2023 - Springer
Objective Establishing cell lines with enhanced protein production requires a deep
understanding of the cellular dynamics and cell line stability. The aim of the study is to …

AFM image analysis of porous structures by means of neural networks

M Giergiel, B Zapotoczny, I Czyzynska-Cichon… - … Signal Processing and …, 2022 - Elsevier
In this work, we presented a method of finding and characterising transmembrane porous
structures, called fenestrations, with the help of convolutional neural networks. Case studies …

High-throughput viscoelastic characterization of cells in hyperbolic microchannels

F Reichel, R Goswami, S Girardo, J Guck - Lab on a Chip, 2024 - pubs.rsc.org
Extensive research has demonstrated the potential of cell viscoelastic properties as intrinsic
indicators of cell state, functionality, and disease. For this, several microfluidic techniques …

Multi‐scale characterization and analysis of cellular viscoelastic mechanical phenotypes by atomic force microscopy

Y Zeng, X Liu, Z Wang, W Gao, S Zhang… - Microscopy …, 2024 - Wiley Online Library
The viscoelasticity of cells serves as a biomarker that reveals changes induced by malignant
transformation, which aids the cytological examinations. However, differences in the …

A multiscale modeling to determine in vitro mechanical responses of different cells at the cell‐substrate interface under fluid perfusion

A Gupta, A Barui, RK Banerjee, A Das… - … Research Part B …, 2024 - Wiley Online Library
Investigating the influence of different cellular mechanical and physical properties on cells in
vitro is important for assessing cellular activities like differentiation, proliferation, and …

Cellular actin cytoskeleton morphology identification for mechanical characterization using deep learning

Y Liu, J Zhang, C Bharat, J Ren - IEEE Access, 2022 - ieeexplore.ieee.org
Actin cytoskeleton morphology is able to affect and reflect the cellular mechanical properties.
However, due to the lack of efficient approaches to quantifying actin cytoskeleton and …

Finite element analysis of the influence of cyclic strain on cells anchored to substrates with varying properties

A Banerjee, MP Khan, A Barui, P Datta… - Medical & Biological …, 2022 - Springer
The response of cytoskeleton to mechanical cues plays a pivotal role in understanding
several aspects of cellular growth, migration, and cell–cell and cell–matrix interactions under …

Quantifying cytoskeletal organization from optical microscopy data

S Desroches, AR Harris - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
The actin cytoskeleton plays a pivotal role in a broad range of physiological processes
including directing cell shape and subcellular organization, determining cell mechanical …