Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

Proteomes are complex—much more so than genomes or transcriptomes. Thus, simplifying
their analysis does not simplify the issue. Proteomes are of proteoforms, not canonical …

Recent advances in designing metamaterials have demonstrated that global mechanical
properties of disordered spring networks can be tuned by selectively modifying only a small …

It is not often realized that the absolute protein specificity is an exception rather than a rule.
Two major kinds of protein multi-specificities are promiscuity and moonlighting. This review …

Moonlighting proteins are defined as proteins with two or more functions that are unrelated
and independent to each other, so that inactivation of one of them should not affect the …

In recent years, mass spectrometry-based proteomics has provided scientists with the
tremendous capability to study plants more precisely than previously possible. Currently …

Peroxiredoxin 6 (Prdx6) is a Ca 2+-independent intracellular phospholipase A 2 (called
aiPLA 2) that is localized to cytosol, lysosomes, and lysosomal-related organelles. Activity is …

The excretion of cytoplasmic and signal-peptide-less proteins (ECP) by microorganisms and
eukaryotes remains a fascinating topic. In principle, it appears to be a waste of energy …

Adenosine is an endogenous purine nucleoside that acts in all living systems as a
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …

Significant amounts of enolase—a cytosolic enzyme involved in the glycolysis pathway—are
exposed on the cell surface of Candida yeast. It has been hypothesized that this exposed …