Risk factors for progression of age‐related macular degeneration

TJ Heesterbeek, L Lorés‐Motta… - Ophthalmic and …, 2020 - Wiley Online Library
Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula,
often leading to progressive vision loss. The rate of disease progression can vary among …

[HTML][HTML] The progression of geographic atrophy secondary to age-related macular degeneration

M Fleckenstein, P Mitchell, KB Freund, SV Sadda… - Ophthalmology, 2018 - Elsevier
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD)
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …

[HTML][HTML] Quantitative approaches in multimodal fundus imaging: state of the art and future perspectives

A Arrigo, E Aragona, MB Parodi, F Bandello - Progress in Retinal and Eye …, 2023 - Elsevier
When it first appeared, multimodal fundus imaging revolutionized the diagnostic workup and
provided extremely useful new insights into the pathogenesis of fundus diseases. The recent …

Determinants of quantitative optical coherence tomography angiography metrics in patients with diabetes

FY Tang, DS Ng, A Lam, F Luk, R Wong, C Chan… - Scientific reports, 2017 - nature.com
Early microvascular damage in diabetes (eg capillary nonperfusion and ischemia) can now
be assessed and quantified with optical coherence tomography-angiography (OCT-A). The …

Incidence and growth of geographic atrophy during 5 years of comparison of age-related macular degeneration treatments trials

JE Grunwald, M Pistilli, E Daniel, GS Ying, W Pan… - Ophthalmology, 2017 - Elsevier
Purpose To estimate the incidence, size, and growth rate of geographic atrophy (GA) during
5 years of follow-up among participants in the Comparison of Age-Related Macular …

Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials

JE Grunwald, M Pistilli, G Ying, MG Maguire, E Daniel… - Ophthalmology, 2015 - Elsevier
Purpose To evaluate the growth of geographic atrophy (GA) during anti–vascular
endothelial growth factor (VEGF) therapy. Design Cohort within a clinical trial. Participants …

Quantitative optical coherence tomography angiography of macular vascular structure and foveal avascular zone in glaucoma

J Choi, J Kwon, JW Shin, J Lee, S Lee, MS Kook - PloS one, 2017 - journals.plos.org
Objective The study aimed to evaluate the quantitative characteristics of the macular vessel
density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence …

Progression of photoreceptor degeneration in geographic atrophy secondary to age-related macular degeneration

M Pfau, L von der Emde, L de Sisternes… - JAMA …, 2020 - jamanetwork.com
Importance Sensitive outcome measures for disease progression are needed for treatment
trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) …

Alterations of the foveal avascular zone measured by optical coherence tomography angiography in glaucoma patients with central visual field defects

J Kwon, J Choi, JW Shin, J Lee… - … ophthalmology & visual …, 2017 - iovs.arvojournals.org
Purpose: To investigate whether the area and shape of the foveal avascular zone (FAZ) as
assessed by optical coherence tomography angiography (OCTA) are altered in …

Anatomic clinical trial endpoints for nonexudative age-related macular degeneration

KB Schaal, PJ Rosenfeld, G Gregori, Z Yehoshua… - Ophthalmology, 2016 - Elsevier
Topic To review the role of anatomic endpoints in clinical trials for the study of nonexudative
age-related macular degeneration (AMD) with an emphasis on a novel composite endpoint …