Gene–environment interactions in human health
Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
Statistical methods for gene–environment interaction analysis
Most human complex phenotypes result from multiple genetic and environmental factors and
their interactions. Understanding the mechanisms by which genetic and environmental …
their interactions. Understanding the mechanisms by which genetic and environmental …
High-Dimensional Gene–Environment Interaction Analysis
M Wu, Y Li, S Ma - Annual Review of Statistics and Its …, 2024 - annualreviews.org
Beyond the main genetic and environmental effects, gene–environment (G–E) interactions
have been demonstrated to significantly contribute to the development and progression of …
have been demonstrated to significantly contribute to the development and progression of …
Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging
Introduction: Vitamin C is an essential nutrient. Sex differences in serum vitamin C
concentrations have been observed but are not fully known. Investigation of levels of …
concentrations have been observed but are not fully known. Investigation of levels of …
Many roads to a gene-environment interaction
KE Westerman, T Sofer - The American Journal of Human Genetics, 2024 - cell.com
Despite the importance of gene-environment interactions (GxEs) in improving and
operationalizing genetic discovery, interpretation of any GxEs that are discovered can be …
operationalizing genetic discovery, interpretation of any GxEs that are discovered can be …
Re-analysis and meta-analysis of summary statistics from gene–environment interaction studies
DT Pham, KE Westerman, C Pan, L Chen… - …, 2023 - academic.oup.com
Motivation Summary statistics from genome-wide association studies enable many valuable
downstream analyses that are more efficient than individual-level data analysis while also …
downstream analyses that are more efficient than individual-level data analysis while also …
Summary statistics from large-scale gene-environment interaction studies for re-analysis and meta-analysis
DT Pham, KE Westerman, C Pan, L Chen, S Srinivasan… - medRxiv, 2023 - medrxiv.org
Abstract Summary statistics from genome-wide association studies enable many valuable
downstream analyses that are more efficient than individual-level data analysis while also …
downstream analyses that are more efficient than individual-level data analysis while also …