▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

The skin has long been recognized as a major producer of cytokines, but the keratinocyte as
principal epidermal cell has received less attention as potential source and target of …

Abstract IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that
have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

The melanoma differentiation-associated gene 7 (mda-7) has been studied primarily in the
context of its tumor suppressor activity. Although mda-7 has been designated as IL-24 based …

Due to their structural similarity, interleukin (IL)‐19, IL‐20, IL‐22, IL‐24 and IL‐26 were
combined with IL‐10 in the so‐called IL‐10 family. To expand the knowledge on IL‐19, IL …

Five novel cytokines (IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat
C49A/Mob-5), and IL-26 (AK155)) demonstrating limited primary sequence identity and …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

The melanoma differentiation-associated gene-7 (mda-7; approved gene symbol IL24) is a
tumor suppressor gene whose expression induces selective apoptosis in tumor cells. To …

Human melanoma cells growth arrest irreversibly, lose tumorigenic potential and terminally
differentiate after treatment with a combination of fibroblast interferon (IFN-β) and the protein …