Corruption of the dentate gyrus by “dominant” granule cells: Implications for dentate gyrus function in health and disease

HE Scharfman, CE Myers - Neurobiology of learning and memory, 2016 - Elsevier
The dentate gyrus (DG) and area CA3 of the hippocampus are highly organized lamellar
structures which have been implicated in specific cognitive functions such as pattern …

Tonic inhibitory control of dentate gyrus granule cells by α5-containing GABAA receptors reduces memory interference

E Engin, ED Zarnowska, D Benke… - Journal of …, 2015 - Soc Neuroscience
Interference between similar or overlapping memories formed at different times poses an
important challenge on the hippocampal declarative memory system. Difficulties in …

Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding

K McAvoy, A Besnard, A Sahay - Frontiers in systems neuroscience, 2015 - frontiersin.org
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate
granule cells (DGCs) throughout life. Behavioral studies using the contextual fear …

Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity

S Chavlis, PC Petrantonakis, P Poirazi - Hippocampus, 2017 - Wiley Online Library
The hippocampus plays a key role in pattern separation, the process of transforming similar
incoming information to highly dissimilar, nonverlapping representations. Sparse firing …

Disynaptic effect of hilar cells on pattern separation in a spiking neural network of hippocampal dentate gyrus

SY Kim, W Lim - Cognitive Neurodynamics, 2022 - Springer
We study the disynaptic effect of the hilar cells on pattern separation in a spiking neural
network of the hippocampal dentate gyrus (DG). The principal granule cells (GCs) in the DG …

Cell numbers in the reflected blade of CA3 and their relation to other hippocampal principal cell populations across seven species

J Maliković, I Amrein, L Vinciguerra… - Frontiers in …, 2023 - frontiersin.org
The hippocampus of many mammals contains a histoarchitectural region that is not present
in laboratory mice and rats—the reflected blade of the CA3 pyramidal cell layer. Pyramidal …

Long-term cognitive, emotional and neurogenic alterations induced by alcohol and methamphetamine exposure in adolescent rats

D Loxton, JJ Canales - Progress in Neuro-Psychopharmacology and …, 2017 - Elsevier
A high proportion of young methamphetamine (MA) users simultaneously consume alcohol.
However, the potential neurological and behavioural alterations induced by such a drug …

Dynamical origin for winner-take-all competition in a biological network of the hippocampal dentate gyrus

SY Kim, W Lim - Physical Review E, 2022 - APS
We consider a biological network of the hippocampal dentate gyrus (DG). Computational
models suggest that the DG would be a preprocessor for pattern separation (ie, a process …

Effect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus

SY Kim, W Lim - Cognitive Neurodynamics, 2024 - Springer
Young immature granule cells (imGCs) appear via adult neurogenesis in the hippocampal
dentate gyrus (DG). In comparison to mature GCs (mGCs)(born during development), the …

Population and individual firing behaviors in sparsely synchronized rhythms in the hippocampal dentate gyrus

SY Kim, W Lim - Cognitive Neurodynamics, 2022 - Springer
We investigate population and individual firing behaviors in sparsely synchronized rhythms
(SSRs) in a spiking neural network of the hippocampal dentate gyrus (DG). The main …