Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear
receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent …

Abstract Protein Arginine Methyltransferases (PRMTs) are a family of enzymes regulating
protein arginine methylation, which is a post-translational modification crucial for various …

Despite the immense success of immune checkpoint blockade (ICB) in cancer treatment,
many tumors, including melanoma, exhibit innate or adaptive resistance. Tumor-intrinsic T …

Cancer has become a leading cause of death and disease burden worldwide, closely
related to rapid socioeconomic development. However, the fundamental reason is the lack …

Abstract Protein arginine methyltransferase 1 (PRMT1), the predominant type I protein
arginine methyltransferase, plays a crucial role in normal biological functions by catalyzing …

In recent studies, erianin, a natural product isolated from Dendrobium chrysotoxum Lindl,
has exhibited notable anticancer properties. Ferroptosis, a novel form of programmed cell …

Increasing evidence suggests the oncogenic role of missense mutation (AKT1-E17K) of
AKT1 gene in meningiomas. Upon investigating the connection between the pro …

Background Ubiquitination plays an important role in proliferating and invasive characteristic
of glioblastoma (GBM), similar to many other cancers. Tripartite motif 25 (TRIM25) is a …

Glioblastoma is a highly aggressive and malignant type of brain cancer that originates from
glial cells in the brain, with a median survival time of 15 months and a 5-year survival rate of …

Glioma is the most prevalent primary malignant tumor of the central nervous system. While
traditional treatment modalities such as surgical resection, radiotherapy, and chemotherapy …