Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged
worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS …

Migration and positioning of immune cells is fundamental for their differentiation and
recruitment at sites of infection. Besides the fundamental role played by chemokines and …

Eosinophils are innate immune granulocytes actively involved in defensive responses and
in local and systemic inflammatory processes. Beyond these effector roles, eosinophils are …

Allergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2
immune responses and characterized by eosinophilic pulmonary inflammation, airway …

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and …

The purinergic system is composed of purine and pyrimidine transmitters, the enzymes that
modulate the interconversion of nucleotides and nucleosides, the membrane transporters …

Increasing evidence shows that polycystic ovary syndrome (PCOS) is often accompanied by
an inflammatory response, hence, appropriately managing granulosa cell inflammation is …

Since the late 1970s, there has been an alarming increase in the incidence of asthma and
its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways …