Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its
ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

Autosomal dominant periodic fever syndromes are characterized by unexplained episodes
of fever and severe localized inflammation. In seven affected families, we found six different …

The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory
reaction in the synovium of joints and is associated with degeneration of cartilage and …

The aim of this study was to investigate whether interleukin (IL)-6 induces the production of
IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from …

Background: In a phase II study, etanercept (recombinant human tumor necrosis factor
receptor [p75]: Fc fusion protein) safely produced rapid, dose-dependent improvement in …

Background A recombinant, soluble fusion protein that is a dimer of an extracellular portion
of the human tumor necrosis factor (TNF) receptor and the Fc portion of IgG1 (TNFR: Fc) …

Background Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the
pathogenesis of rheumatoid arthritis, and antagonism of TNF may reduce the activity of the …

Background & Aims: We evaluated etanercept, a human soluble tumor necrosis factor
receptor: Fc fusion protein, for the treatment of active Crohn's disease. Methods: Forty-three …