This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

In bacteria, fungi and animals, 3′-5′-cyclic adenosine monophosphate (cAMP) and
adenylate cyclases (ACs), enzymes that catalyse the formation of 3′, 5′-cAMP from ATP …

Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

Neuronal polarization establishes distinct molecular structures to generate a single axon
and multiple dendrites. Studies over the past years indicate that this efficient separation is …

A wide diversity of perturbations of the central nervous system (CNS) result in structural
damage to the neuroarchitecture and cellular defects, which in turn are accompanied by …

The microdomain that orchestrates action potential initiation in neurons is the axon initial
segment (AIS). It has long been considered to be a rather homogeneous domain at the very …

A single microRNA (miRNA) can regulate expression of multiple proteins and expression of
an individual protein may be controlled by numerous miRNAs. This regulatory pattern …

Cyclic AMP (cAMP) and protein kinase A (PKA), classical examples of spatially
compartmentalized signaling molecules, are critical axon determinants that regulate …

The PDE4 cyclic nucleotide phosphodiesterases are essential regulators of cAMP
abundance in the CNS through their ability to regulate PKA activity, the phosphorylation of …

The generation of axonal and dendritic domains is critical for brain circuitry assembly and
physiology. Negative players, such as the RhoA-Rho coiled-coil-associated protein kinase …