The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism
and its environment. Continuing studies have highlighted the regulation of the tight junction …

Spermiation—the release of mature spermatozoa from Sertoli cells into the seminiferous
tubule lumen—occurs by the disruption of an anchoring device known as the apical …

Tissue integrity relies on barriers formed between epithelial cells. In the testis, the barrier is
formed at the initiation of puberty by a tight junction complex between adjacent Sertoli cells …

A wide spectrum of data in the literature shows the relevance of cytokines as paracrine
regulators of spermatogenesis and steroidogenesis in the normal testis. In this brief review …

The testis is an important male reproductive organ, which ensures reproductive function via
the secretion of testosterone and the generation of spermatozoa. Testis development begins …

Many male infertility cases have no apparent cause, being characterized as idiopathic. Both
inflammation and obesity have long been associated with infertility. On one hand …

Anchoring junctions are cell adhesion apparatus present in all epithelia and endothelia.
They are found at the cell–cell interface (adherens junction (AJ) and desmosome) and cell …

Viral infections have been a part of human existence to date, though viruses have posed a
huge threat with various outbreaks lately. These threats are associated with reproductive …