The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

The mechanisms contributing to transcription-associated genomic instability are both
complex and incompletely understood. Although R-loops are normal transcriptional …

Transcription-coupled nucleotide excision repair (TC-NER) is initiated by the stalling of
elongating RNA polymerase II (RNAPIIo) at DNA lesions. The ubiquitination of RNAPIIo in …

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by
promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 …

The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is
crucial for proper execution of the DNA damage-induced stress response. While stalling of …

G‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences
that fold into a four‐stranded conformation. Experimental studies and computational …

BRCA1 is a major breast and ovarian cancer susceptibility gene, with mutations in this gene
predisposing women to a very high risk of developing breast and ovarian tumours. BRCA1 …

An E3 ubiquitin ligase mediates the transfer of activated ubiquitin from an E2 ubiquitin-
conjugating enzyme to its substrate lysine residues. Using a structure-based, yeast two …

The exact functions of BRCA1 have not been fully described but it now seems apparent that
it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most …