Molecular insight of regorafenib treatment for colorectal cancer

H Arai, F Battaglin, J Wang, JH Lo, S Soni… - Cancer treatment …, 2019 - Elsevier
Regorafenib is a multi-targeting kinase inhibitor approved for the treatment of metastatic
colorectal cancer patients in refractory to standard chemotherapy. Similarly to sorafenib, this …

KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation

M Miettinen, J Lasota - Applied immunohistochemistry & molecular …, 2005 - journals.lww.com
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells

L Song, D Coppola, S Livingston, WD Cress… - Cancer biology & …, 2005 - Taylor & Francis
Overexpression of anti-apoptotic Bcl-2 family members and deregulation of the pathways
that regulate pro-apoptotic family members have been observed in non-small cell lung …

Extracellular matrix protein βig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation

C Ma, Y Rong, DR Radiloff, MB Datto… - Genes & …, 2008 - genesdev.cshlp.org
Metastasis, the major cause of cancer death, is a multistep process that requires interactions
between cancer cells and stromal cells and between cancer cells and extracellular matrix …

[HTML][HTML] Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness

H Siemens, R Jackstadt, M Kaller, H Hermeking - Oncotarget, 2013 - ncbi.nlm.nih.gov
The c-Kit receptor tyrosine kinase is commonly over-expressed in different types of cancer.
p53 activation is known to result in the down-regulation of c-Kit. However, the underlying …

KITLG is a novel target of miR‐34c that is associated with the inhibition of growth and invasion in colorectal cancer cells

S Yang, W Li, F Dong, H Sun, B Wu… - Journal of Cellular …, 2014 - Wiley Online Library
MiR‐34c is considered a potent tumour suppressor because of its negative regulation of
multiple target m RNA s that are critically associated with tumorigenesis and metastasis. In …

KIT signaling promotes growth of colon xenograft tumors in mice and is up-regulated in a subset of human colon cancers

EC Chen, TA Karl, T Kalisky, SK Gupta, CA O'Brien… - Gastroenterology, 2015 - Elsevier
Background & Aims Receptor tyrosine kinase (RTK) inhibitors have advanced colon cancer
treatment. We investigated the role of the RTK KIT in development of human colon cancer …

Regional distribution of interstitial cells of Cajal (ICC) in human stomach

HY Yun, R Sung, YC Kim, W Choi… - The Korean Journal …, 2010 - synapse.koreamed.org
We elucidated the distribution of interstitial cells of Cajal (ICC) in human stomach, using
cryosection and c-Kit immunohistochemistry to identify c-Kit positive ICC. Before c-Kit …

Autocrine Interleukin-6/Interleukin-6 Receptor Stimulation in Non–Small-Cell Lung Cancer

EB Haura, S Livingston, D Coppola - Clinical lung cancer, 2006 - Elsevier
Autocrine growth factor stimulation resulting in growth self-sufficiency is a hallmark of
cancer. Classically, non–small-cell lung cancer (NSCLC) cells have autocrine epidermal …

c-Kit is suppressed in human colon cancer tissue and contributes to L1-mediated metastasis

N Gavert, A Shvab, M Sheffer, A Ben-Shmuel, G Haase… - Cancer research, 2013 - AACR
The transmembrane neural cell adhesion receptor L1 is a Wnt/β-catenin target gene
expressed in many tumor types. In human colorectal cancer, L1 localizes preferentially to the …