Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
S Fragki, H Dirven, T Fletcher… - Critical reviews in …, 2021 - Taylor & Francis
Associations between per-and polyfluoroalkyl substances (PFASs) and increased blood
lipids have been repeatedly observed in humans, but a causal relation has been debated …
lipids have been repeatedly observed in humans, but a causal relation has been debated …
[HTML][HTML] Animal models to study bile acid metabolism
J Li, PA Dawson - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2019 - Elsevier
The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …
role in studying the relationship between bile acid metabolism and human liver disease …
[HTML][HTML] Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions
Hepatocytes, the major metabolic hub of the body, execute functions that are human-
specific, altered in human disease, and currently thought to be regulated through endocrine …
specific, altered in human disease, and currently thought to be regulated through endocrine …
Effect of different bile acids on the intestine through enterohepatic circulation based on FXR
J Xiang, Z Zhang, H Xie, C Zhang, Y Bai, H Cao… - Gut …, 2021 - Taylor & Francis
Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely
expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide …
expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide …
CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo—Brief Report
Objective—Although early proof-of-concept studies of somatic in vivo genome editing of the
mouse ortholog of proprotein convertase subtilisin/kexin type 9 (Pcsk9) in mice have …
mouse ortholog of proprotein convertase subtilisin/kexin type 9 (Pcsk9) in mice have …
[PDF][PDF] Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
N Oehler, T Volz, OD Bhadra, J Kah, L Allweiss… - …, 2014 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection has been associated with alterations in lipid
metabolism. Moreover, the Na+‐taurocholate cotransporting polypeptide (NTCP) …
metabolism. Moreover, the Na+‐taurocholate cotransporting polypeptide (NTCP) …
A drug screen using human iPSC-derived hepatocyte-like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia
Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been
hampered by the lack of models. However, cells with hepatocyte characteristics can be …
hampered by the lack of models. However, cells with hepatocyte characteristics can be …
[HTML][HTML] Extensive double humanization of both liver and hematopoiesis in FRGN mice
Preclinical research in animals often fails to adequately predict the outcomes observed in
human patients. Chimeric animals bearing individual human tissues have been developed …
human patients. Chimeric animals bearing individual human tissues have been developed …
Fibroblast growth factor signaling controls liver size in mice with humanized livers
WE Naugler, BD Tarlow, LM Fedorov, M Taylor, C Pelz… - Gastroenterology, 2015 - Elsevier
Background & Aims The ratio of liver size to body weight (hepatostat) is tightly controlled, but
little is known about how the physiologic functions of the liver help determine its size. Livers …
little is known about how the physiologic functions of the liver help determine its size. Livers …
Fibroblast growth factor 15/19 expression, regulation, and function: an overview
Since the discovery of fibroblast growth factor (FGF)-19 over 20 years ago, our
understanding of the peptide and its role in human biology has moved forward significantly …
understanding of the peptide and its role in human biology has moved forward significantly …