Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

The tumormicroenvironment (TME) plays a key role in tumor progression. Tumor-associated
macrophages (TAMs), which are natural immune cells abundantin the TME, are mainly …

The codependency of cholesterol metabolism sustains the malignant progression of
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …

Atherosclerotic arterial plaques and malignant solid tumors contain macrophages, which
participate in anaerobic metabolism, acidosis, and inflammatory processes inherent in the …

Cholesterol is often enriched in tumor microenvironment (TME); however, its impact on
disease progression varies in different tissues and cells. Monocytes/macrophages (Mφ) are …

Glioblastoma multiforme (GBM) is notoriously resistant to immunotherapy due to its intricate
immunosuppressive tumor microenvironment (TME). Dysregulated cholesterol metabolism …

Human endogenous retroviruses (HERVs) comprise about 8.3% of the human genome and
are capable of producing RNA molecules that can be sensed by pattern recognition …

Background Lipid metabolism has been implicated in a variety of normal cellular processes
and strongly related to the development of multiple diseases, including tumor. Tumor …

Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide.
Although immunotherapy has increased the overall survival of patients with lung cancer …

Background Preclinical and clinical translational research supports the role of an ω-3 fatty
acid diet for prostate cancer prevention and treatment. The anti-prostate cancer effects of an …