Insights into manganese superoxide dismutase and human diseases

M Liu, X Sun, B Chen, R Dai, Z Xi, H Xu - International Journal of …, 2022 - mdpi.com
Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Persistent pulmonary hypertension of the newborn: pathophysiological mechanisms and novel therapeutic approaches

S Martinho, R Adão, AF Leite-Moreira… - Frontiers in …, 2020 - frontiersin.org
Persistent pulmonary hypertension of the newborn (PPHN) is one of the main causes of
neonatal morbidity and mortality. It is characterized by sustained elevation of pulmonary …

Identification of OLA1 as a Novel Protein Target of Vitexin to Ameliorate Dextran Sulfate Sodium-Induced Colitis with Tissue Thermal Proteome Profiling

N Li, R Wang, W Li, Q Du, Z Deng, Y Fan… - Journal of Agricultural …, 2023 - ACS Publications
Vitexin, which exists in various medicinal plants and food sources, has recently received
increasing attention because of its anti-inflammatory properties. This study aims to identify …

Sex dimorphism in pulmonary hypertension: the role of the sex chromosomes

DS Kostyunina, P McLoughlin - Antioxidants, 2021 - mdpi.com
Pulmonary hypertension (PH) is a condition characterised by an abnormal elevation of
pulmonary artery pressure caused by an increased pulmonary vascular resistance …

Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae

S Dannenmaier, CD Altamirano, L Schüler… - Journal of Biological …, 2021 - ASBMB
The universally conserved P-loop ATPase Ola1 is implicated in various cellular stress
response pathways, as well as in cancer and tumor progression. However, Ola1p functions …

OLA1 phosphorylation governs the mitochondrial bioenergetic function of pulmonary vascular cells

P Sidlowski, A Czerwinski, Y Liu, P Liu… - American Journal of …, 2023 - atsjournals.org
Mitochondrial function and metabolic homeostasis are integral to cardiovascular function
and influence how vascular cells respond to stress. However, little is known regarding how …

The Role of the Universally conserved ATPase YchF/Ola1 in translation regulation during cellular stress

V Landwehr, M Milanov, J Hong, HG Koch - Microorganisms, 2021 - mdpi.com
The ability to respond to metabolic or environmental changes is an essential feature in all
cells and involves both transcriptional and translational regulators that adjust the metabolic …

Identification and development of Tetra-ARMS PCR-based screening test for a genetic variant of OLA1 (Tyr254Cys) in the human failing heart

PK Dubey, S Dubey, S Singh, PD Bhat, S Pogwizd… - PloS one, 2024 - journals.plos.org
Obg-like ATPase 1 (OLA1) protein has GTP and ATP hydrolyzing activities and is important
for cellular growth and survival. The human OLA1 gene maps to chromosome 2 (locus 2q31 …

Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

J Cao, L Yang, L Wang, Q Zhao… - Molecular …, 2021 - spandidos-publications.com
Pulmonary microvascular endothelial cell (PMVEC) apoptosis is the initial stage of adult
pulmonary hypertension (PH), which involves high pulmonary arterial pressure and …

OLA1 is a potential prognostic molecular biomarker for endometrial cancer and promotes tumor progression

Y Dong, A Yin, C Xu, H Jiang, Q Wang… - Oncology …, 2021 - spandidos-publications.com
Abstract Obg‑like ATPase 1 (OLA1) is upregulated in the tumor tissues in different types of
cancer. However, the function of OLA1 and its molecular mechanisms in endometrial cancer …