Targeting cyclin-dependent kinases in human cancers: from small molecules to peptide inhibitors

M Peyressatre, C Prével, M Pellerano, MC Morris - Cancers, 2015 - mdpi.com
Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The tetratricopeptide repeat: a structural motif mediating protein‐protein interactions

GL Blatch, M Lässle - Bioessays, 1999 - Wiley Online Library
The tetratricopeptide repeat (TPR) motif is a protein‐protein interaction module found in
multiple copies in a number of functionally different proteins that facilitates specific …

Cyclin A in cell cycle control and cancer

CH Yam, TK Fung, RYC Poon - Cellular and Molecular Life Sciences …, 2002 - Springer
Cyclin A is particularly interesting among the cyclin family because it can activate two
different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An …

Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae

MD Mendenhall, AE Hodge - Microbiology and Molecular Biology …, 1998 - Am Soc Microbiol
The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of
cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the …

The plant cell cycle

W Dewitte, JAH Murray - Annual review of plant biology, 2003 - annualreviews.org
Cell division in plants is controlled by the activity of cyclin-dependent kinase (CDK)
complexes. Although this basic mechanism is conserved with all other eukaryotes, plants …

Linking cyclins to transcriptional control

O Coqueret - Gene, 2002 - Elsevier
Cell cycle activation is coordinated by D-type cyclins which are rate limiting and essential for
the progression through the G1 phase of the cell cycle. D-type cyclins bind to and activate …

Segment-based stereo matching using graph cuts

L Hong, G Chen - Proceedings of the 2004 IEEE Computer …, 2004 - ieeexplore.ieee.org
In this paper we present a new segment-based stereo matching algorithm using graph cuts.
In our approach, the reference image is divided into non-overlapping homogeneous …

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

ME Garber, P Wei, VN KewalRamani… - Genes & …, 1998 - genesdev.cshlp.org
HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of
the TAK/P-TEFb CTD kinase complex. Here we show that the cyclin domain of hCycT1 is …

The domains of death: evolution of the apoptosis machinery

L Aravind, VM Dixit, EV Koonin - Trends in biochemical sciences, 1999 - cell.com
Recent progress in research into programmed cell death has resulted in the identification of
the principal protein domains involved in this process. The evolution of many of these …

[HTML][HTML] Structure and regulation of the CDK5-p25nck5a complex

C Tarricone, R Dhavan, J Peng, LB Areces, LH Tsai… - Molecular cell, 2001 - cell.com
CDK5 plays an indispensable role in the central nervous system, and its deregulation is
involved in neurodegeneration. We report the crystal structure of a complex between CDK5 …