Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …

It is well established that CD8+ T cells constitute an important branch of adaptive immunity
contributing to clearance of intracellular pathogens and providing long-term protection …

Immune-mediated inflammatory diseases (IMIDs) are referred to as highly disabling chronic
diseases affecting different organs and systems. Inappropriate or excessive immune …

T cell–derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA)
pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we …

Until recently, little was known about the importance of CD8+ T effectors in promoting and
preventing autoimmune disease development. CD8+ T cells can oppose or promote …

Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the
tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease associated with
damage to multiple organs and glands. The most common clinical manifestations are dry …

Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …