Advanced glycation end products (AGEs) contribute to lens protein pigmentation and cross-
linking during aging and cataract formation. In vitro experiments have shown that ascorbate …

Quantitative metabolomic profiles of normal and cataractous human lenses were obtained
with the combined use of high-frequency nuclear magnetic resonance (NMR) and high …

This work is the first comprehensive report on the quantitative metabolomic composition of
the rat lens. Quantitative metabolomic profiles of lenses were acquired with the combined …

Introduction The optical elements of the eye—cornea, lens, and vitreous humor—are
avascular tissues, and their nutrition and waste removal are provided by aqueous humor …

The excited-state dynamics of kynurenine (KN) has been examined in various solvents by
femtosecond-resolved optical spectroscopy. The lifetime of the S1 state of KN amounts to 30 …

Photoinduced generation of radicals in the eye lens may play an important role in the
modification of proteins leading to their coloration, aggregation, and insolubilization. The …

An eye lens is constantly exposed to the solar UV radiation, which is considered the most
important external source of age-related changes to eye lens constituents. The accumulation …

Purpose.: To compare the photochemical properties of UV filter molecules present in the
human lens (kynurenine, KN; 3-hydroxykynurenine, 3OHKN; 3-hydroxykynurenine O-β-d …

Introduction The analysis of post-mortem metabolomic changes in biological fluids opens
the way to develop new methods for the estimation of post-mortem interval (PMI). It may also …

The reactions of photoexcited kynurenic acid (KNA) with bovine α-crystallins under
anaerobic conditions proceed via the electron transfer from tryptophan (Trp) and tyrosine …