The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

Changes in postsynaptic membrane composition underlie many forms of learning-related
synaptic plasticity in the brain. At excitatory glutamatergic synapses, fusion of intracellular …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …

Pancreatic β‐cells secrete insulin by Ca2+‐dependent exocytosis of secretory granules. β‐
cell exocytosis involves SNARE (soluble NSF‐attachment protein receptor) proteins similar …

The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of
cells and has multiple biological functions that may be important in inflammation and in the …

The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein
family is of vital importance for organelle communication. The complexing of cognate …

Type 2 diabetes has been coined “a two-hit disease,” as it involves specific defects of
glucose-stimulated insulin secretion from the pancreatic beta cells in addition to defects in …

Dendritic exocytosis is required for a broad array of neuronal functions including retrograde
signaling, neurotransmitter release, synaptic plasticity, and establishment of neuronal …