Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …

The presence and function of CB2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB2 receptor messenger RNA and protein …

CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …

Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …

Considerable evidence demonstrates that manipulation of the endocannabinoid system
regulates nausea and vomiting in humans and other animals. The anti‐emetic effect of …

Coinciding with the increasing rates of cannabis abuse has been the recognition of a new
clinical condition known as Cannabinoid Hyperemesis Syndrome. Cannabinoid …

Cannabis is commonly used in cyclic vomiting syndrome (CVS) due to its antiemetic and
anxiolytic properties. Paradoxically, chronic cannabis use in the context of cyclic vomiting …

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

BACKGROUND AND PURPOSE To evaluate the hypothesis that activation of
somatodendritic 5‐HT1A autoreceptors in the dorsal raphe nucleus (DRN) produces the anti …