Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

Surgery is the oldest oncological discipline, dating back thousands of years. Prior to the
advent of anaesthesia and antisepsis 150 years ago, only the brave, desperate, or ill …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Abstract Background: The CanRisk Tool (https://canrisk. org) is the next-generation web
interface for the latest version of the BOADICEA (Breast and Ovarian Analysis of Disease …

Background The purpose of this study was to estimate precise age-specific tubo-ovarian
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …

The risk of breast and ovarian cancer among women with mutations such as BRCA1 and
BRCA2 mutations can be mitigated by operations to remove the organs at greatest risk. Data …

Women at high risk of developing breast cancer are a heterogeneous group of women
including those with and without high-risk germline mutation/s. Prevention in these women …

Purpose To characterise the prevalence of pathogenic germline mutations in BRCA1 and
BRCA2 in families with breast cancer (BC) and ovarian cancer (OC) history. Patients and …