Attenuated strains of the naturally occurring plant pathogen Agrobacterium tumefaciens can
transfer virtually any DNA sequence of interest to model plants and crops. This has made …

The fidelity of genetic information is essential for cellular function and viability. DNA double-
strand breaks (DSBs) pose a significant threat to genome integrity, necessitating efficient …

Microhomology-mediated end joining (MMEJ) is an intrinsically mutagenic pathway of DNA
double-strand break (DSB) repair essential for proliferation of homologous recombination …

The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with
homologous recombination (HR) factors and is therefore a promising drug target in …

DNA double-stranded breaks (DSBs) are a particularly challenging form of DNA damage to
repair because the damaged DNA must not only undergo the chemical reactions …

G0-G1 phase alternative end joining (A-EJ) is a recently defined mutagenic pathway
characterized by resected deletion and translocation joints that are predominantly direct and …

Genomic structural variants (SVs) greatly impact human health, but much is unknown about
the mechanisms that generate the largest class of nonrecurrent alterations. Common fragile …

Identifying the mechanisms of action of anticancer drugs is an important step in the
development of new drugs. In this study, we established a comprehensive screening …

Cellular and biochemical studies of nonhomologous DNA end joining (NHEJ) have long
established that nuclease and polymerase action are necessary for the repair of a very large …

During lymphocyte development, diverse primary repertoires of antigen receptors are
created by V (D) J recombination. In the first phase of the V (D) J recombination reaction …