Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Recent advances in radiometals for combined imaging and therapy in cancer

N Herrero Álvarez, D Bauer, J Hernández‐Gil… - …, 2021 - Wiley Online Library
Nuclear medicine is defined as the use of radionuclides for diagnostic and therapeutic
applications. The imaging modalities positron emission tomography (PET) and single …

ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

[HTML][HTML] Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Y Xiao, Y Liu, Z Gao, X Li, M Weng, C Shi… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of
chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence …

Why bother with alpha particles?

AP King, FI Lin, FE Escorcia - European Journal of Nuclear Medicine and …, 2021 - Springer
The approval of 223 RaCl 2 for cancer therapy in 2013 has heralded a resurgence of
interest in the development of α-particle emitting radiopharmaceuticals. In the last decade …

[HTML][HTML] Perspectives on metals-based radioimmunotherapy (RIT): moving forward

JM White, FE Escorcia, NT Viola - Theranostics, 2021 - ncbi.nlm.nih.gov
Radioimmunotherapy (RIT) is FDA-approved for the clinical management of liquid
malignancies, however, its use for solid malignancies remains a challenge. The putative …

iNOS regulates the therapeutic response of pancreatic cancer cells to radiotherapy

PMR Pereira, KJ Edwards, K Mandleywala, LM Carter… - Cancer research, 2020 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiotherapy,
chemotherapy, or a combination of these modalities, and surgery remains the only curative …

Acute statin treatment improves antibody accumulation in EGFR-and PSMA-expressing tumors

PMR Pereira, K Mandleywala, A Ragupathi… - Clinical Cancer …, 2020 - AACR
Purpose: Statins are cholesterol-depleting drugs used to treat patients with
hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell …

Therapeutic application of monoclonal antibodies in pancreatic cancer: advances, challenges and future opportunities

GA Arias-Pinilla, H Modjtahedi - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic cancer is a leading cause of cancer death worldwide. In the
majority of patients, cancers are diagnosed at advanced stages of disease and are resistant …