Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

The large amount of data published in the last 10–15 years indicate that myosin isoforms are
the major determinant of the large functional heterogeneity of the key contractile and …

Passive tension in striated muscles derives primarily from the extension of the giant protein
titin. However, several studies have suggested that, in cardiac muscle, interactions between …

The molecular mechanism by which Ca 2+ binding and phosphorylation regulate muscle
contraction through Troponin is not yet fully understood. Revealing the differences between …

The effects of aging on the mechanical properties of myosin were measured in 87 fibers from
muscles of humans (n= 40), rats (n= 21), and mice (n= 26) using a single fiber in vitro motility …

Myosin binding protein-C (MyBP-C) is a thick-filament protein whose precise function within
the sarcomere is not known. However, recent evidence from cMyBP-C knock-out mice that …

Contraction of striated muscles is initiated by an increase in cytosolic Ca2+ concentration,
which is regulated by tropomyosin and troponin acting on actin filaments at the sarcomere …

The beating heart exhibits remarkable contractile fidelity over a lifetime, which reflects the
tight coupling of electrical, chemical, and mechanical elements within the sarcomere, the …

The effect of the type of metal ion (ie, Ca2+, Mg2+, or none) bound to the high-affinity
divalent cation binding site (HAS) of actin on filament assembly, structure, and dynamics …

Background Prolonged controlled mechanical ventilation (CMV) in humans and
experimental animals results in diaphragm fibre atrophy and injury. In animals, prolonged …