Environmental exposures and mechanisms in allergy and asthma development

LB Murrison, EB Brandt, JB Myers… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Environmental exposures interplay with human host factors to promote the development and
progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a …

Monocytes and macrophages in COVID-19: Friends and foes

S Meidaninikjeh, N Sabouni, HZ Marzouni, S Bengar… - Life sciences, 2021 - Elsevier
The COVID-19 is a novel infectious disease caused by SARS-CoV-2 and is known as a
pandemic emergency that has led to a high rate of mortality throughout the world. Evidence …

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

MC Madison, CT Landers, BH Gu… - The Journal of …, 2020 - Am Soc Clin Investig
Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular
recreational tool among adolescents and adults. Although the use of ENDS is often …

γδ T cells regulate the intestinal response to nutrient sensing

ZA Sullivan, W Khoury-Hanold, J Lim, C Smillie… - Science, 2021 - science.org
INTRODUCTION The gastrointestinal (GI) tract is a multikingdom cellular ecosystem that
facilitates the procurement of nutrients from the environment. In constant contact with the …

Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches

A Sabbaghi, SM Miri, M Keshavarz, M Mahooti… - Virology journal, 2020 - Springer
Background Influenza virus infection is among the most detrimental threats to the health of
humans and some animals, infecting millions of people annually all around the world and in …

Adenosine at the interphase of hypoxia and inflammation in lung injury

X Li, NK Berg, T Mills, K Zhang, HK Eltzschig… - Frontiers in …, 2021 - frontiersin.org
Hypoxia and inflammation often coincide in pathogenic conditions such as acute respiratory
distress syndrome (ARDS) and chronic lung diseases, which are significant contributors to …

Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

Y Zhao, L Lin, Z Xiao, M Li, X Wu, W Li… - Journal of …, 2018 - Wiley Online Library
γδ T cells, a subgroup of T cells based on the γδ TCR, when compared with conventional T
cells (αβ T cells), make up a very small proportion of T cells. However, its various subgroups …

SARS-CoV-2 infection: host response, immunity, and therapeutic targets

P Shivshankar, H Karmouty-Quintana, T Mills… - Inflammation, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a global pandemic with …

TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung

R Xu, LC Jacques, S Khandaker, D Beentjes… - Cell Reports, 2023 - cell.com
Streptococcus pneumoniae is a pathogen of global morbidity and mortality. Pneumococcal
pneumonia can lead to systemic infections associated with high rates of mortality. We find …

Alveolar macrophages in lung cancer: opportunities and challenges

CY Chang, D Armstrong, DB Corry… - Frontiers in …, 2023 - frontiersin.org
Alveolar macrophages (AMs) are critical components of the innate defense mechanism in
the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow …