The adhesive interactions of cells with other cells and with the extracellular matrix are crucial
to all developmental processes, but have a central role in the functions of the immune …

A major prediction of the fluid mosaic model of membrane structure Ill was that proteins
would interact with the lipid bilayer only by non-covalent interactions. For most proteins (the …

Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic disease characterized
by abnormal blood cell populations in which the biosynthesis of the …

Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many
proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of …

Paroxysmal nocturnal haemoglobinuria (PNH), an acquired clonal blood disorder, is caused
by the absence of glycosyl phosphatidylinositol (GPI)‐anchored surface proteins due to a …

The scrapie agent protein (Sp33-37 or PrPSC) is the disease-associated isoform of a normal
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …

Background Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder in which
there is a deficiency in the synthesis by hematopoietic cells of the glycosyl …

We have used an in vitro model system of glass-supported planar membranes to study the
effects of lateral mobility of membrane-bound receptors on cell adhesion. Egg …

Many cell surface proteins are anchored to the membrane via a glycosylphosphatidylinositol
(GPI) moiety, which is attached to the C terminus of the proteins. The core of the GPI anchor …