T Watanabe, M Kiso, S Fukuyama, N Nakajima, M Imai… - Nature, 2013 - nature.com
Avian influenza A viruses rarely infect humans; however, when human infection and subsequent human-to-human transmission occurs, worldwide outbreaks (pandemics) can …
Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Widespread outbreaks (pandemics) are attributable to 'novel'viruses that possess a …
VCC Cheng, KKW To, H Tse, IFN Hung… - Clinical microbiology …, 2012 - Am Soc Microbiol
The world had been anticipating another influenza pandemic since the last one in 1968. The pandemic influenza A H1N1 2009 virus (A/2009/H1N1) finally arrived, causing the first …
R Xu, X Zhu, R McBride, CM Nycholat, W Yu… - Journal of …, 2012 - Am Soc Microbiol
The 2009 H1N1 influenza pandemic is the first human pandemic in decades and was of swine origin. Although swine are believed to be an intermediate host in the emergence of …
Y Liu, RA Childs, T Matrosovich, S Wharton… - Journal of …, 2010 - Am Soc Microbiol
Mutations in the receptor-binding site of the hemagglutinin of pandemic influenza A (H1N1) 2009 viruses have been detected sporadically. An Asp222Gly (D222G) substitution has …
Influenza virus hemagglutinin (HA) is the viral envelope protein that mediates viral attachment to host cells and elicits membrane fusion. The HA receptor-binding specificity is …
CR Cotter, H Jin, Z Chen - PLoS pathogens, 2014 - journals.plos.org
The 2009 H1N1 pandemic (H1N1pdm) viruses have evolved to contain an E47K substitution in the HA2 subunit of the stalk region of the hemagglutinin (HA) protein. The biological …
M Hong, PS Lee, RMB Hoffman, X Zhu… - Journal of …, 2013 - Am Soc Microbiol
Influenza virus is a global health concern due to its unpredictable pandemic potential. This potential threat was realized in 2009 when an H1N1 virus emerged that resembled the 1918 …