Prodrug strategies for targeted therapy triggered by reactive oxygen species

JP Cadahía, V Previtali, NS Troelsen, MH Clausen - MedChemComm, 2019 - pubs.rsc.org
Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …

Sensors, imaging agents, and theranostics to help understand and treat reactive oxygen species related diseases

KC Yan, AC Sedgwick, Y Zang, GR Chen… - Small …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions
and free radicals that are produced throughout the body during certain biological processes …

Prodrugs for targeted cancer therapy

C Souza, DS Pellosi, AC Tedesco - Expert review of anticancer …, 2019 - Taylor & Francis
Introduction: Prodrugs have been used to improve the selectivity and efficacy of cancer
therapy by targeting unique abnormal markers that are overexpressed by cancer cells and …

Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic …

Q Tang, HL Zhang, Y Wang, J Liu, SP Yang… - Journal of Materials …, 2021 - pubs.rsc.org
A multifunctional nanoplatform (1), MnCO@ TPP@ C–TiO2, which consists of a carrier of
carbon-doped TiO2 nanoparticles with surface covalent functionalization of manganese …

Singlet oxygen-activatable Paclitaxel prodrugs via intermolecular activation for combined PDT and chemotherapy

M Bio, KMM Rahman, I Lim, P Rajaputra… - Bioorganic & Medicinal …, 2019 - Elsevier
Systemic side effects and high hydrophobicity are major disadvantages of paclitaxel (PTX),
one of the most popular anticancer drugs. Here, we present singlet oxygen (SO)-activatable …

Development of prodrugs for PDT-based combination therapy using a singlet-oxygen-sensitive linker and quantitative systems pharmacology

L Nguyen, M Li, S Woo, Y You - Journal of Clinical Medicine, 2019 - mdpi.com
Photodynamic therapy (PDT) has become an effective treatment for certain types of solid
tumors. The combination of PDT with other therapies has been extensively investigated in …

PBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug

M Li, L Nguyen, B Subramaniyan, M Bio… - Journal of Controlled …, 2019 - Elsevier
Photodynamic therapy (PDT) is a clinically approved therapeutic modality to treat certain
types of cancers. However, incomplete ablation of tumor is a challenge. Visible and near IR …

A quantitative pharmacology model of exosome-mediated drug efflux and perturbation-induced synergy

J Wang, BZ Yeung, MG Wientjes, M Cui, CJ Peer, Z Lu… - Pharmaceutics, 2021 - mdpi.com
Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as
drug carriers. We used experimental and computational studies to investigate the kinetics of …

Local and Systemic Antitumor Effects of Photo‐activatable Paclitaxel Prodrug on Rat Breast Tumor Models

B Subramaniyan, P Rajaputra, L Nguyen… - Photochemistry and …, 2020 - Wiley Online Library
We demonstrated that a large primary and a small untreated distant breast cancer could be
controlled by local treatment with our light‐activatable paclitaxel (PTX) prodrug. We …

[图书][B] Development of Multifunctional Phthalocyanine-Based Theranostic Agents for Cancer Imaging and Therapy

YY Ha - 2020 - search.proquest.com
Phthalocyanines are highly versatile functional dyes which have found many practical
applications in various disciplines, ranging from materials science to medicine and …