Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Elevation in homocysteine (Hcy) level is associated with insulin resistance; however, the
causality between them and the underlying mechanism remain elusive. Here, we show that …

Diabetes Mellitus (DM) is a complex disease with a significant impact in today's world.
Studies have emphasized the crucial role of genetics in DM, unraveling the distinction of …

Abstract HNF4A and HNF1A encode transcription factors that are important for the
development and function of the pancreas and liver. Mutations in both genes have been …

Pancreatic β cells are specialized for coupling glucose metabolism to insulin peptide
production and secretion. Acute glucose exposure robustly and coordinately increases …

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …

HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes
(HNF1A–maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A …

Renal defects in maturity onset diabetes of the young 3 (MODY3) patients and Hnf1a-/-mice
suggest an involvement of HNF1A in kidney development and/or its function. Although …

Introduction Monogenic diabetes, a form of diabetes mellitus, is caused by a mutation in a
single gene and may account for 1–2% of all clinical forms of diabetes. To date, more than …

Glucose metabolism in fish remains a controversial area of research as many fish species
are traditionally considered glucose-intolerant. Although energy homeostasis remodeling …