Brain pericytes reside on the abluminal surface of capillaries, and their processes cover~
90% of the length of the capillary bed. These cells were first described almost 150 years ago …

Inactivation of voltage‐gated ion channels is an intrinsic auto‐regulatory process necessary
to govern the occurrence and shape of action potentials and establish firing patterns in …

Abstract Background Cav1. 3 voltage-gated L-type calcium channels (LTCCs) are part of
postsynaptic neuronal signaling networks. They play a key role in brain function, including …

Timothy Syndrome (TS) is a multisystem disorder, prominently featuring cardiac action
potential prolongation with paroxysms of life-threatening arrhythmias. The underlying defect …

Abstract Cav1. 2 L-type calcium channels play key roles in long-term synaptic plasticity,
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …

Calcium-dependent inactivation (CDI) is a fundamental autoregulatory mechanism in Ca V 1
and Ca V 2 voltage-gated calcium channels. Although CDI initiates with the cytoplasmic …

Voltage-gated Na and Ca2+ channels represent two major ion channel families that enable
myriad biological functions including the generation of action potentials and the coupling of …

Ca2+-binding protein 2 (CaBP2) inhibits the inactivation of heterologously expressed
voltage-gated Ca2+ channels of type 1.3 (CaV1. 3) and is defective in human autosomal …

The first pathogenic mutation in CaV1. 2 was identified in 2004 and was shown to cause a
severe multisystem disorder known as Timothy syndrome (TS). The mutation was localized …

Cav1. 2 Ca2+ channels, a type of voltage-gated L-type Ca2+ channel, are ubiquitously
expressed, and the predominant Ca2+ channel type, in working cardiac myocytes. Cav1. 2 …