An epigenetic role of mitochondria in cancer

Y Liu, C Chen, X Wang, Y Sun, J Zhang, J Chen, Y Shi - Cells, 2022 - mdpi.com
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis

R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …

A Nanotherapy of Octanoic Acid Ameliorates Cardiac Arrest/Cardiopulmonary Resuscitation-Induced Brain Injury via RVG29- and Neutrophil Membrane-Mediated …

J Yang, P Wang, X Jiang, J Xu, M Zhang, F Liu, Y Lin… - ACS …, 2023 - ACS Publications
Treatment of cardiac arrest/cardiopulmonary resuscitation (CA/CPR)-induced brain injury
remains a challenging issue without viable therapeutic options. Octanoic acid (OA), a lipid …

Mesenchymal stem cells under epigenetic control–the role of epigenetic machinery in fate decision and functional properties

A Walewska, A Janucik, M Tynecka, M Moniuszko… - Cell Death & …, 2023 - nature.com
Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …

The role of reprogrammed glucose metabolism in cancer

MK Ediriweera, S Jayasena - Metabolites, 2023 - mdpi.com
Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various
microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by …

From multi-omics approaches to personalized medicine in myocardial infarction

C Zhan, T Tang, E Wu, Y Zhang, M He, R Wu… - Frontiers in …, 2023 - frontiersin.org
Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …

[HTML][HTML] Functional crosstalk between chromatin and hypoxia signalling

H Collier, A Albanese, CS Kwok, J Kou, S Rocha - Cellular Signalling, 2023 - Elsevier
Eukaryotic genomes are organised in a structure called chromatin, comprising of DNA and
histone proteins. Chromatin is thus a fundamental regulator of gene expression, as it offers …

The role of myocardial regeneration, cardiomyocyte apoptosis in acute myocardial infarction: A review of current research trends and challenges

D Yan, S Zhan, C Guo, J Han, L Zhan, Q Zhou… - Journal of …, 2024 - Elsevier
Purpose This paper aims to review the research progress in repairing injury caused by acute
myocardial infarction, focusing on myocardial regeneration, cardiomyocyte apoptosis, and …

miRNAs epigenetic tuning of wall remodeling in the early phase after myocardial infarction: A Novel epidrug approach

F Salvatori, E D'Aversa, ML Serino, AV Singh… - International Journal of …, 2023 - mdpi.com
Myocardial infarction (MI) is one of the leading causes of death in Western countries. An
early diagnosis decreases subsequent severe complications such as wall remodeling or …

[HTML][HTML] N-acetyl-aspartate metabolism at the interface of cancer, immunity, and neurodegeneration

N Krause, A Wegner - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•The exact functional role of NAA in metabolism is unclear.•NAA substantially
impacts cellular signaling.•Elevated NAA levels influence tumor–macrophage …