Peptide therapeutics is currently one of the fastest growing markets worldwide and
consequently convenient ways of administration for these drugs are highly on demand. In …

Receptor activity-modifying proteins (RAMP1–3) determine the selectivity of the class BG
protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR) for calcitonin …

Purpose A novel, non-reversible, aqueous-based lipidization strategy with palmitic acid as a
model lipid was evaluated for conjugation with salmon calcitonin (sCT). Materials and …

Acylation of proteins with a fatty acid chain has proven useful for prolonging the plasma half-
lives of proteins. In formulation of acylated protein drugs, knowledge about the effect of …

Purpose To study the effect of acylation on the adsorption of insulin to hydrophobic
polystyrene beads. Methods Adsorption isotherms for adsorption of insulin and acylated …

Mass spectrometry using matrix-assisted laser desorption/ionization (MALDI) is a
widespread technique for various types of proteomic analysis. In the identification of proteins …

Reversible aqueous lipidization (REAL) at the interdisulfide bond has been shown to
improve the deliverability of some peptide drugs. Recently, we developed a nonreversible …

Objectives The aim of the study was to explore (1) the synthesis of a novel poly (ethylene
glycol) modified lipid (PEG-lipid, PL) containing a chemically active tri-block linker, ε …

Proteins are macromolecules with diverse roles within the human body, responsible for
many roles including catalysing biological reactions, acting as cell surface receptors, cell …

Background: With more countries in the world entering elderly society, osteoporosis is a
common disease among the elderly, especially middle-aged and elderly women. Although …