The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR)
antagonists described in the literature. They exhibit micromolar affinities and are non …

Drug addiction is a serious brain disorder with somatic, psychological, psychiatric, socio-
economic and legal implications in the developed world. Illegal (eg, psychostimulants …

Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on
affinity/potency and selectivity of AR ligands described in the literature has been obtained for …

The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium
tuberculosis (Mtb) while 5-nitroimidazoles like metronidazole are active against only …

Adenosine A2A receptors are highly concentrated in the striatum, where they play an
important modulatory role of glutamatergic transmission to the GABAergic enkephalinergic …

Adenosine A 1 receptors are attracting great interest as drug targets for their role in cognitive
deficits. Antagonism of the adenosine A 1 receptor may offer therapeutic benefits in complex …

Adenosine is a neuromodulator that interacting with four receptors, A1, A2A, A2B and A3, is
involved in the regulation of several biological functions in different organs and tissues …

Three category of N 1-phenyl pyrazoline (5a–e), N 1-phenyl-sulfonyl pyrazoline (6a–e), and
pyridine analogs (8a–d) of combretastatin-A4 were synthesized. The structures of …

The development of potent and selective agonists and antagonists of adenosine receptors
(ARs) has been a target of medicinal chemistry research for several decades, and recently …

The adenosine A 2A receptor is considered to be an important target for the development of
new therapies for Parkinson's disease. Several antagonists of the A 2A receptor have …