The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …

Background Although several randomised trials in patients with triple-negative breast cancer
have shown that the addition of carboplatin, with or without poly (ADP-ribose) polymerase …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Thioredoxin‐interacting protein (TXNIP) was originally named vitamin D3 upregulated
protein‐1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX …

XRCC1 is a molecular scaffold protein that assembles multi-protein complexes involved in
DNA single-strand break repair,. Here we show that biallelic mutations in the human XRCC1 …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

The mitochondrial permeability transition pore is a high conductance channel whose
opening leads to an increase of mitochondrial inner membrane permeability to solutes with …