Arterial hypertension and brain damage—evidence from animal models
F Amenta, MA Di Tullio, D Tomassoni - Clinical and experimental …, 2003 - Taylor & Francis
Hypertension is an important risk factor for cerebrovascular disease including stroke and
has also a role in the development of vascular cognitive impairment (VCI) and vascular …
has also a role in the development of vascular cognitive impairment (VCI) and vascular …
The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?
SM Williams, JL Haines, JH Moore - Bioessays, 2004 - Wiley Online Library
The study of the genetics of complex human disease has met with limited success. Many
findings with candidate genes fail to replicate despite seemingly overwhelming …
findings with candidate genes fail to replicate despite seemingly overwhelming …
Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
MP Ocaranza, J Moya, V Barrientos… - Journal of …, 2014 - journals.lww.com
Background: Little is known about the biological effects of angiotensin-(1–9), but available
evidence shows that angiotensin-(1–9) has beneficial effects in preventing/ameliorating …
evidence shows that angiotensin-(1–9) has beneficial effects in preventing/ameliorating …
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1–9) axis in experimental hypertension
MP Ocaranza, P Rivera, U Novoa, M Pinto… - Journal of …, 2011 - journals.lww.com
Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme
(ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and …
(ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and …
[HTML][HTML] Antihipertensivos en pacientes con COVID-19
A Ramírez-Sagredo, A Ramírez-Reyes… - Revista chilena de …, 2020 - SciELO Chile
En 31 de diciembre del 2019 la Organización Mundial de la Salud fue informada por las
autoridades sanitarias chinas de la aparición de casos de neumonía de origen desconocido …
autoridades sanitarias chinas de la aparición de casos de neumonía de origen desconocido …
Rho‐kinase pathway activation and apoptosis in circulating leucocytes in patients with heart failure with reduced ejection fraction
MP Ocaranza, J Moya, JE Jalil… - Journal of Cellular …, 2020 - Wiley Online Library
Abstract Background Increased Rho‐kinase activity in circulating leucocytes is observed in
heart failure with reduced ejection fraction (HFrEF). However, there is little information in …
heart failure with reduced ejection fraction (HFrEF). However, there is little information in …
Simultaneous Rho kinase inhibition in circulating leukocytes and in cardiovascular tissue in rats with high angiotensin converting enzyme levels
C Fierro, U Novoa, V González, MP Ocaranza… - International journal of …, 2016 - Elsevier
Background The small guanosine triphosphatase RhoA and its direct target Rho kinase
(ROCK) play important roles in cardiovascular pathophysiology. Activated ROCK …
(ROCK) play important roles in cardiovascular pathophysiology. Activated ROCK …
Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats
MP Ocaranza, G Díaz-Araya… - American Journal …, 2004 - journals.physiology.org
In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in
cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE …
cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE …
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan
P Wang, F Tang, R Li, H Zhang, S Chen, P Liu… - Pharmacological …, 2007 - Elsevier
Growing evidences have shown that hypertension, cardiac hypertrophy and fibrosis were
associated with an overactivity of NAD (P) H oxidase. It is unknown, however, which isoform …
associated with an overactivity of NAD (P) H oxidase. It is unknown, however, which isoform …
Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I–converting enzyme levels
The RhoA/Rho kinase (ROCK) pathway is a new mechanism of remodeling and
vasoconstriction. Few data are available regarding ROCK activation when angiotensin I …
vasoconstriction. Few data are available regarding ROCK activation when angiotensin I …