Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …

Telomeres, protective DNA-protein complexes at the end of eukaryotic linear chromosomes,
play pivotal roles in the maintenance of genomic stability during cell division. When …

Replicative senescence is an essential cellular process playing important physiological
functions, but it is better known for its implications in aging, cancer, and other pathologies …

A percentage of colorectal cancer (CRC) patients display low sensitivity to radiotherapy,
which affects its therapeutic effect. Cancer cells DNA double-strand breaks (DSBs) repair …

In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated
genome has been faithfully replicated and evenly distributed before they complete their …

Loss of telomeric DNA leads to telomere uncapping, which triggers a persistent, p53-centric
DNA damage response that sustains a stable senescence-associated proliferation arrest …

Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage
to the nervous system, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Early work by Muller and McClintock discovered that the physical ends of linear
chromosomes, named telomeres, possess an inherent ability to escape unwarranted …

Checkpoints arrest biological processes, allowing time for error correction. The
phenomenon of checkpoint override during cellular self-replication is biologically critical, but …

Rdh54 is a conserved DNA translocase that participates in homologous recombination (HR),
DNA checkpoint adaptation, and chromosome segregation. Saccharomyces cerevisiae …