Pharmaceutical cocrystals: An overview

N Qiao, M Li, W Schlindwein, N Malek, A Davies… - International journal of …, 2011 - Elsevier
Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved
physicochemical properties, which has attracted increased interests from both industrial and …

Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size

B Sinha, RH Müller, JP Möschwitzer - International journal of pharmaceutics, 2013 - Elsevier
The solubility dependent bioavailability problem has become a major hurdle in drug
development processes. Drug nanocrystals have been widely accepted by the …

Solubility advantage of amorphous drugs and pharmaceutical cocrystals

NJ Babu, A Nangia - Crystal Growth & Design, 2011 - ACS Publications
The current phase of drug development is witnessing an oncoming crisis due to the
combined effects of increasing R&D costs, decreasing number of new drug molecules being …

Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals–a comprehensive review

L Padrela, MA Rodrigues, A Duarte, AMA Dias… - Advanced drug delivery …, 2018 - Elsevier
Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective

AA Thorat, SV Dalvi - Chemical Engineering Journal, 2012 - Elsevier
The liquid antisolvent (LAS) precipitation process for production of ultra-fine particles has
been widely researched for a last few decades. In LAS process, precipitation of solute is …

Production methods for nanodrug particles using the bottom-up approach

HK Chan, PCL Kwok - Advanced drug delivery reviews, 2011 - Elsevier
This review focuses on bottom-up processes such as precipitation (or crystallisation) and
single droplet evaporation to produce nanoparticles containing largely pure therapeutics for …

Nanosizing techniques for improving bioavailability of drugs

R Al-Kassas, M Bansal, J Shaw - Journal of controlled release, 2017 - Elsevier
The poor solubility of significant number of Active Pharmaceutical Ingredients (APIs) has
become a major challenge in the drug development process. Drugs with poor solubility are …

[图书][B] Handbook on applications of ultrasound: sonochemistry for sustainability

D Chen, SK Sharma, A Mudhoo - 2011 - books.google.com
Providing up-to-date information on ultrasound technology and sonochemistry, this volume
focuses on green chemistry principles and methodologies that are being devised with a view …

[HTML][HTML] Etravirine-loaded dissolving microneedle arrays for long-acting delivery

S Rojekar, LK Vora, IA Tekko, F Volpe-Zanutto… - European Journal of …, 2021 - Elsevier
A key challenge of HIV treatment with multiple antiretroviral drugs is patient adherence.
Thus, there is an urgent need for long-acting depot systems for delivering drugs over an …

Microfluidics for pharmaceutical nanoparticle fabrication: The truth and the myth

SI Hamdallah, R Zoqlam, P Erfle, M Blyth… - International journal of …, 2020 - Elsevier
Using micro-sized channels to manipulate fluids is the essence of microfluidics which has
wide applications from analytical chemistry to material science and cell biology research …