DoubleHelix: nucleic acid sequence identification, assignment and validation tool for cryo-EM and crystal structure models
G Chojnowski - Nucleic acids research, 2023 - academic.oup.com
Sequence assignment is a key step of the model building process in both cryogenic electron
microscopy (cryo-EM) and macromolecular crystallography (MX). If the assignment fails, it …
microscopy (cryo-EM) and macromolecular crystallography (MX). If the assignment fails, it …
Novel chimeric proteins mimicking SARS-CoV-2 spike epitopes with broad inhibitory activity
M Cano-Muñoz, D Polo-Megías… - International Journal of …, 2022 - Elsevier
Abstract SARS-CoV-2 spike (S) protein mediates virus attachment to the cells and fusion
between viral and cell membranes. Membrane fusion is driven by mutual interaction …
between viral and cell membranes. Membrane fusion is driven by mutual interaction …
The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans
S Rehman, AK Antonovic, IE McIntire, H Zheng… - Nature …, 2024 - nature.com
Bacterial adhesion is a fundamental process which enables colonisation of niche
environments and is key for infection. However, in Legionella pneumophila, the causative …
environments and is key for infection. However, in Legionella pneumophila, the causative …
RNA and RNA-protein complexes Principles of ion binding to RNA inferred from the analysis of a 1.55 Å resolution bacterial ribosome structure - Part I: Mg2+
F Leonarski, A Henning-Knechtel… - Nucleic Acids …, 2024 - cnrs.hal.science
The importance of Mg 2+ ions for RNA structure and function cannot be overstated. Several
attempts were made to establish a comprehensive Mg 2+ binding motif classification …
attempts were made to establish a comprehensive Mg 2+ binding motif classification …
[HTML][HTML] TRBP2, a Major Component of the RNAi Machinery, Is Subjected to Cell Cycle-Dependent Regulation in Human Cancer Cells of Diverse Tissue Origin
Abstract Background: Transactivation Response Element RNA-binding Protein (TRBP2) is a
double-stranded RNA-binding protein widely known for its critical contribution to RNA …
double-stranded RNA-binding protein widely known for its critical contribution to RNA …
RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines
P Nievergelt, F Berliat, KE McAuley… - …, 2024 - Wiley Online Library
All widely used mRNA vaccines against COVID‐19 contain in their sequence 1‐
methylpseudouridine (m1Ψ) instead of uridine. In this publication, we report two high …
methylpseudouridine (m1Ψ) instead of uridine. In this publication, we report two high …
AQuaRef: Machine learning accelerated quantum refinement of protein structures
Cryo-EM and X-ray crystallography provide crucial experimental data for obtaining atomic-
detail models of biomacromolecules. Refining these models relies on library-based …
detail models of biomacromolecules. Refining these models relies on library-based …
[HTML][HTML] The Legionella collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans
S Rehman, AK Antonovic, IE McIntire, H Zheng… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Bacterial adhesion is a fundamental process which enables colonisation of niche
environments and is key for infection. However, in Legionella pneumophila, the causative …
environments and is key for infection. However, in Legionella pneumophila, the causative …
PDB‐REDO in Computational‐Aided Drug Design (CADD)
The PDB‐REDO databank (https://pdb‐redo. eu) is a publicly available repository of
optimized crystallographic macromolecular structure models from the Protein Data Bank …
optimized crystallographic macromolecular structure models from the Protein Data Bank …
Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins
The four human Argonaute (AGO) proteins, essential in RNA interference and gene
regulation, exhibit high sequence and structural similarity, yet differ functionally. Our …
regulation, exhibit high sequence and structural similarity, yet differ functionally. Our …